Below are some articles that I can suggest if you want to consider designing for flexible screen sizes. The evolt page below will return search results that include articles on why "640 x 480 Isn't Dead Just Yet," "Liquid Design for the Web," "Liquid Tables" and "Design to realistic window sizes." All good stuff if you want to see how to do designs that aren't locked into a resolution quite as much. I'm not doing anything but some personal blogs so far, but these are things I'm considering for our first commercial blog(s)...
http://evolt.org/search/node/liquid+design
Granted, some of it's a long read, some a little tech/nerdie (okay, I like that), and it's focused on mainstream sites, so I'm mentioning it knowing it's not for everyone.
Simon