Supporting a few browser engines like Gecko, Khtml, Opera, and IE is what I try to support.
Linux is growing fast. Not a lot of use now but it is expected to explode in a few years. There is no IE for Linux, just Gecko, Khtml. Opera and a few others.
Personally I'm a Mac user and use Safari which is based Khtml and use Mozilla for a couple of admins that don't work with Safari.
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