Yes, that is a hack attempt, specifically an attempt to find certain cgi scripts or folder that indicate certain programs are loaded. On positive hits, they will log them and perhaps come back later to explore potential vunerabilities that they can use to gain access to your system and do what they like.
The most common hack right now is the additonal or installation of a 1X1 frame on the bottom of TGPs. That frame loaded a toolbar / malware as well as other "features" that you don't want. It uses a known hack to install on IE without permission and without notice.
Keep your eyes open.
Alex
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