I am currently building all our members areas to be responsive, next we will work on the tours, after that the galleries. We will be generating our own traffic in-house, then move into the affiliate market once all the work is done. Entering this industry, or re-entering it seems vital to use the latest standards, and everything it has to offer. Responsive design has a lot of advantages. The HTML5/CSS3/JS combo is quite the magician if you ask me. Faster load times and adding/omitting content per "viewport" size. This doesn't necessarily have anything to do with mobile "per se". However, think of xbox, playstation, roku, google tv, handheld systems with internet browsing capabilities... and old farts who still run commodores in 640x480 screen resolutions.
If you plan on being in any online biz for any reasonable lenght of time, start building with new technologies, which may or may not include responsive designs, but interactive animation, div layers, html5 video and the possibilies there-in. SO MUCH TO LEARN, so don't waste any time.
