Depends on what country you are targeting. Remember Australia, New Zealand, Great Britain, etc all speak English and will sign up to US sites, but there 6-1 is a lot different to the USA's 6-1.
For example, I sell a lot on eBay, and for the type of thing I sell it is best to list between 11pm and 1am. But because most of what I sell I can sell internationally by listings are spread between 11pm and 9am my local time (3pm and 1am pst).
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