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Stu - make sure that when you run those programs like cwshredder and hijackthis as well as spysweeper and your antivirus that you do it from safe mode (just start your computer and tap F8 a few times to get to the menu to choose safe mode) and make sure you are not connected to your net connection - if you have more than one user account on your computer you will also need to run those programs as the admin first and then each user
After you have removed everything (I sure wish you could post exactly what type of symptoms you are having besides being slow like any popups, or any particular virus/trojan being identified) I would run the hijackthis and post a copy of the log here or you can pm it to me
I would not recommend a system restore unless you are sure you have a good clean version - most of the good trojans these days attach themselves to the backup files first to ensure they stick around after a restore
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