Not many places will reject you outright because of poor recip grouping, but it's a good idea to group according to size/traffic. Some of the biggies might reject if they're constantly grouped with nothing but no-name LLs.
Once in a while you'll come across a smaller LL with outrageous grouping requirements, my advice would be to drop them.
Personally I don't give it much thought as long as the LLs I'm grouped with are real, live sites accepting submits.
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