Possible, yes. Good idea? up to you.
you could define a particular class as display:none;
<a href="asdf" style="display:none;">misspelled</a>
you could define it in a separate layer where the layer isn't active, i.e. a css popup that is never activated. Search engines would still see it. Perhaps using absolute positioning to place it off the page.
Now, the problem is that what you want to do looks like spam to many of the search engines.
You might be able to do something like a disambiguation page... perhaps
Alternate spellings:
<a href="#correctlyspelledword">misspelledword</a>
The idea here is that you aren't hiding it from the search engines, it gets the person to where you want them to be. I think of the possibilities, a never-activated CSS popup would probably be the safest, but, I don't know how smart the SE spiders are when it comes to things like that.
All of the other methods I would think their bots are smart enough to recognize that.